회원동정
및 알림
자유게시판
졸업앨범
주소록
 | |
미국 보스턴 의대 최현 박사(류머티즘 전공)가 이끄는 연구팀이 20년간 남성 4만 7000명을 대상으로 조사한 연구 결과다.
연구 기간 동안 통풍에 걸린 남성은 1300여명. 음식이나 비타민 보충제 복용을 통한 비타민 C 섭취량이 1일 평균 250㎎ 이하인 사람에 비해 500~999㎎인 사람의 통풍 발병률은 17% 더 낮았다. 1000~1499㎎인 사람은 34%, 1500㎎(1.5g) 이상인 사람은 45%나 낮았다. 하루 비타민 C 섭취량이 500mg 증가할 때마다 통풍 발병률은 17%씩 떨어진 셈이다.
연구팀은 비타민 C가 통풍의 원인이 되는 요산의 수치를 낮춰 준다고 말한다. 뿐만 아니라 신장에서의 요산 재흡수에도 영향을 주어 신장 기능을 활성화시켜 염증을 예방한다는 것이다.
이번 연구 결과는 9일 발행된‘내과 의학 기록(Archives of Internal Medicine)’최신호에 게재됐다.
◇통풍=피 속에 요산이 높은 상태가 오래 지속되어 형성된 요산의 결정체가 여러가지 조직에 침착하여 여러가지 증상을 유발하는 대사성 질환. 주로 30대에서 50대 사이의 남성에게 발병한다. 통풍 환자들이 발가락이나 무릎의 통증만을 호소하므로 통풍이 관절만 침범하는 질환으로 오해하기 쉽지만, 몸에 과잉으로 존재하는 요산은 피를 타고 몸의 구석 구석까지 쌓여 머리끝부터 발 끝까지 몸 전체에 통풍의 증상을 일으킬 수 있다. 통풍은 꾸준히 치료 받으면 관절염의 재발을 방지할 수 있을 뿐만 아니라 그 합병증인 신장질환, 요로결석, 동맥경화, 중풍, 고혈압, 심장질환 등도 예방할 수 있다.
디지털뉴스 jdn@joins.com
Vitamin C Intake and the Risk of Gout in Men
A Prospective Study
Hyon K. Choi, MD, DrPH ; Xiang Gao, MD, PhD ; Gary Curhan, MD, ScD
Arch Intern Med. 2009;169(5):502-507. Background Several metabolic studies and a recent double-blind, placebo-controlled, randomized trial have shown that higher vitamin C intake significantly reduces serum uric acid levels. Yet the relation with risk of gout is unknown. Methods We prospectively examined, from1986 through 2006, the relation between vitamin C intake and risk of incident gout in 46 994 male participants with no history of gout at baseline. We used a supplementary questionnaire to ascertain the American College of Rheumatology criteria for gout. Vitamin C intake was assessed every 4 years through validated questionnaires. Results During the 20 years of follow-up, we documented 1317 confirmed incident cases of gout. Compared with men with vitamin C intake less than 250 mg/d, the multivariate relative risk (RR) of gout was 0.83 (95% confidence interval [CI], 0.71-0.97) for total vitamin C intake of 500 to 999 mg/d, 0.66 (0.52-0.86) for 1000 to 1499 mg/d, and 0.55 (0.38-0.80) for 1500 mg/d or greater (P < .001 for trend). The multivariate RR per 500-mg increase in total daily vitamin C intake was 0.83 (95% CI, 0.77-0.90). Compared with men who did not use supplemental vitamin C, the multivariate RR of gout was 0.66 (95% CI, 0.49-0.88) for supplemental vitamin C intake of 1000 to 1499 mg/d and 0.55 (0.36-0.86) for 1500 mg/d or greater (P < .001 for trend). Conclusions Higher vitamin C intake is independently associated with a lower risk of gout. Supplemental vitamin C intake may be beneficial in the prevention of gout.
Authors Affiliations: Division of Rheumatology, Department of Medicine, Arthritis Research Centre of Canada, Vancouver General Hospital, University of British Columbia, Vancouver, Canada (Dr Choi); Channing Laboratory (Drs Choi, Gao, and Curhan) and Renal Division, Department of Medicine (Dr Curhan), Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; and Departments of Epidemiology and Nutrition, Harvard School of Public Health, Boston (Drs Gao and Curhan). Dr Choi is now with the Rheumatology Section, Clinical Epidemiology Unit, Boston University School of Medicine, Boston.
Arch Intern Med. 2009;169(5):502-507. Background Several metabolic studies and a recent double-blind, placebo-controlled, randomized trial have shown that higher vitamin C intake significantly reduces serum uric acid levels. Yet the relation with risk of gout is unknown. Methods We prospectively examined, from1986 through 2006, the relation between vitamin C intake and risk of incident gout in 46 994 male participants with no history of gout at baseline. We used a supplementary questionnaire to ascertain the American College of Rheumatology criteria for gout. Vitamin C intake was assessed every 4 years through validated questionnaires. Results During the 20 years of follow-up, we documented 1317 confirmed incident cases of gout. Compared with men with vitamin C intake less than 250 mg/d, the multivariate relative risk (RR) of gout was 0.83 (95% confidence interval [CI], 0.71-0.97) for total vitamin C intake of 500 to 999 mg/d, 0.66 (0.52-0.86) for 1000 to 1499 mg/d, and 0.55 (0.38-0.80) for 1500 mg/d or greater (P < .001 for trend). The multivariate RR per 500-mg increase in total daily vitamin C intake was 0.83 (95% CI, 0.77-0.90). Compared with men who did not use supplemental vitamin C, the multivariate RR of gout was 0.66 (95% CI, 0.49-0.88) for supplemental vitamin C intake of 1000 to 1499 mg/d and 0.55 (0.36-0.86) for 1500 mg/d or greater (P < .001 for trend). Conclusions Higher vitamin C intake is independently associated with a lower risk of gout. Supplemental vitamin C intake may be beneficial in the prevention of gout.
Authors Affiliations: Division of Rheumatology, Department of Medicine, Arthritis Research Centre of Canada, Vancouver General Hospital, University of British Columbia, Vancouver, Canada (Dr Choi); Channing Laboratory (Drs Choi, Gao, and Curhan) and Renal Division, Department of Medicine (Dr Curhan), Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; and Departments of Epidemiology and Nutrition, Harvard School of Public Health, Boston (Drs Gao and Curhan). Dr Choi is now with the Rheumatology Section, Clinical Epidemiology Unit, Boston University School of Medicine, Boston.
